- November 9, 2018
- Sports nutrition
- David Omarov
In the article we will look at the features of the “Oxymetholone solo” course.
The drug is one of the most powerful androgenic and anabolic steroids. It was first released in the pharmaceutical industry by Syntex Pharmaceuticals in the 1960s under the name Anadrol. It was originally used for medical purposes to stimulate muscle growth in malnourished and weakened patients, as well as in the treatment of osteoporosis and anemia. Oxymethalone was later approved by America's leading FDA committee for drug and food control for human use. After a certain time, more effective drugs were invented, and the steroid began to be used exclusively for sports purposes. However, recent studies have shown its effectiveness in the fight against HIV infection.
We’ll talk about the Oxymetholone course later, but for now let’s look at the history of the discovery and use of the drug.
History of the drug
When Oxymetalon first appeared on the pharmaceutical market, the eyes of both medical workers and athletes were riveted on it. Very quickly, athletes began to use the new steroid, and over fifty years of its use they created the most effective regimens. This fact is confirmed by reviews of the drug.
The anabolic steroid continues to be used today, because, despite all its power, the price of Oxymetholone is quite attractive. The year of its creation is considered to be 1960. Although this happened in Mexico, the steroid was produced by a US company called Syntex.
In addition to athletes, the drug has found its use in the field of medicine, where it was prescribed for the treatment of osteoporosis, anemia, and also to accelerate muscle growth in weakened patients.
At first, Oxymethalon was enthusiastically received by medical workers, as it well accelerated the production of red cells. No other steroid could compare with it in this regard. But the high possibility of unwanted effects negated all the advantages of the product in traditional medicine.
Science developed rapidly, and soon they began to use other means to treat anemia that did not have such an impressive list of possible side effects. As a result, the demand for the drug began to decline, and in 1993 they decided to stop its mass production not only in the USA, but also in a number of other countries.
But the drug was not forgotten, the reason for which was the AIDS epidemic that broke out in the late 90s. From that period to the present, Oxymethalon has been prescribed to patients diagnosed with HIV to slow down the loss of muscle mass.
When it comes to the structure of the molecules of the drug, its structure resembles both drostanolone and stanozolol. There is actually nothing to be surprised here, since Anadrol is a derivative of dihydrotestosterone, like other anabolic steroids. On this basis, one would assume that the drug should not interact with the aromatase enzyme. But the situation in practice turned out to be different, and Oxymetalon has estrogenic properties. Note that the drug does not convert directly into estrogens.
According to the results of many studies, it can be argued that Oxymethalon can activate estrogen receptors. In addition, Anadrol has progestogenic activity, making it similar to nandrolone and trenbolone. The exact mechanism of the progestogenic effect on the body has not been established by scientists, but the drug can probably activate the corresponding receptors, like estrogen ones.
So, what effects can you expect from a course of Oxymetholone?
Description of the steroid profile, composition
Androgenic influence – 45 percent of testosterone.
Anabolic effect – 320 percent of testosterone.
The degree of conversion to estrogens - there is a clear estrogenic effect.
Moderate effects on the liver.
Available in tablet form. Oxymetalon is practically not produced in the form of injections.
The period of detection of a substance during doping control is up to eight weeks.
The duration of operation of Anadrol is fifteen hours.
The drug contains the substance oxymethalone, which began to be widely produced in the 60s. 20th century.
In what cases will a course of Oxymetholone be indicated?
Description and brief history of Oxymetholone
Oxymetholone was first developed by Syntex Pharmaceuticals in 1959 and released to the market in the early 60s. The drug was developed to treat osteoporosis, stimulate muscle growth, increase appetite and treat anemia caused by insufficient production of red blood cells. Such properties of Anadrol are very useful for patients who have weight problems caused by: debilitating diseases (infections), varying degrees of burns, injuries, and also after surgery.
Although anadrol was approved by the FDA for use in humans, later studies were conducted that showed that there are more suitable non-steroidal drugs for the treatment of anemia and osteoporosis, such as epoetin alfa, with a much smaller list of side effects. However, despite the rather impressive list of side effects, oxymetholone is still used in medicine and professional sports. Also, it has proven itself as a drug that supports the health of patients with weakened immunity as a result of HIV infection.
Anadrol is one of the strongest anabolic steroids, and its effectiveness in gaining muscle mass is several times higher than testosterone. So that you understand, the anabolic activity of testosterone is 100%, while for oxymetholone it reaches 320%. In simple terms, anadrol enhances the process of protein synthesis and hypertrophy of muscle fibers so much that the athlete gains weight, roughly speaking, before his eyes. Naturally, in order for all the properties of the drug to manifest themselves fully, it is necessary to follow a regimen, which means: eat right, train heartily, sleep at least 8 hours a day, and everything like that. Now many people believe that the course is a decisive factor in building high-quality muscles, but in reality, it is a whole complex of measures for eating, training and rest. This should not be forgotten.
As already mentioned, the anabolic activity of oxymetholone is three times higher than that of testosterone, while the conversion to estrogens is practically absent. BUT, not everything is so rosy. Despite the minimal aromatization of the drug, there is a negative side in the form of an increase in progestins, just as is the case with trenbolone or nandrolone. So, due to an increase in the level of progestogens, side reactions in the body similar to estrogen may be observed, since progestins are a subclass of female sex hormones.
In addition, oxymetholone is known for its toxic effect on the human liver, which is comparable to methandienone, with the caveat that oxymetholone is used in large dosages, and, therefore, its hepatotoxicity can be many times higher.
This drug is used mainly by experienced, often competitive athletes, since only it is capable of causing significant weight gains in the body, which already has a certain resistance to lighter steroids. The drug is highly valued by pharmacology users due to its ability to immediately begin action and gain weight literally in the first days of use.
By the way, in the world of bodybuilding, anadrol gained great popularity thanks to the advertising of the American bodybuilder Daniel “Dan” Duchaine, nicknamed “Steroid Guru”. He was known for openly talking about the many benefits of using pharmacology, including on television, on shows such as 20/20, Geraldo, 60 Minutes. He can safely be called the father of the modern underground steroid movement. Dan Duchaine promoted oxymetholone as a cheaper alternative to dianabol. There were rumors that he tested anadrol himself, making it in his home. Whether this is true or not, it is impossible to say for sure. There were also rumors that Dan could be the founder of one of the first underground laboratories (UG Labs) in US history. A little historical information: Dan Duchaine passed away due to kidney disease, which he likely acquired from testing and using too many anabolic steroids (including Anadrol).
Steroid profile
- Name: Oxymetholone, anadrol, anadrol, etc.
- Chemical Name: [17 beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one]
- Molecular weight: 332.484 g/mol
- Molecular Formula: C 21 H 32 O 3
- Melting point: 178-180C
- Manufacturer: Syntex (initially), as well as a host of other pharmaceutical companies
- Release date: 1960 Optimal dosage of the drug: 100 mg
- Duration of action: <16 hours
- Half-life (T1/2) (halving the concentration of the substance): 9 hours
- Drug detection time: up to 8 weeks
- Anabolic ratio: 320% of testosterone
- Androgenic coefficient: 35% of the test
- Release form: tablets and oil solution
Effects of use
The following effects of the Oxymetholone course are noted:
- A clear increase in muscle mass. The steroid is perhaps the most effective pill form for gaining muscle volume. You can add up to fifteen kilograms during a course of using the drug. The rollback phenomenon can amount to up to 30 percent of the gain.
- Eliminate pain, improve joint mobility.
- Increase in strength indicators.
- Decreased levels of globulin, which binds sex hormones. This effect makes it possible to significantly increase the functioning of other androgenic and anabolic steroids during the course.
- Stimulates the production of synovial fluid.
The main thing is to follow the instructions when using.
Regimen and dosage
How to use Oxymetholone in bodybuilding? A course of the drug is prescribed to adult athletes without contraindications. Before you start taking it, you need to undergo a full medical examination and consult a specialist. The duration of the course and dosage of the solo drug are determined individually; they depend on pharmacological experience, goals, as well as the specifics of the human body. It is recommended to continue taking it for four to six weeks, the maximum allowable amount is 100 milligrams daily.
As a rule, increasing the norm does not lead to good results; it only increases the likelihood of side effects. Beginners should limit themselves to using Oxymetholone in an amount of 50 mg per day.
When the course of the drug is completed, PCT is required. To restore the level of endogenous testosterone, boosters are taken for three to four weeks. The maximum effect from Oxymethalon will be obtained by following an appropriate diet. The drug is a synergist, as it reduces the content of globulin, which binds sex hormones.
Oxymetholone course for weight
Regarding how to take the drug in combination with other steroids, its use along with 17-alpha-alkylated steroids is not recommended. Taking into account the rapid anabolic effect, the drug is suitable for a “quick start” when training for weight: you can feel its effect almost immediately after use. To gain muscle mass, it is often used with Primobolan, Boldenone and Trenbolone, and to increase strength - with a suspension of stanozolol and testosterone esters (but the first combination is quite dangerous for the ligaments; if the permitted loads are exceeded and used incorrectly, it can cause rupture or damage). Oxymethalon is also often used by bodybuilders immediately before competitions, as it gives fullness to the athlete’s muscles.
Reception scheme
This drug, as mentioned above, is aimed at mass and strength, but weakly interacts with the androgen receptor. Therefore, the drug works well in combination with testosterone, which is very prone to aromatization.
Solo course
The solo course is often used by those trying it for the first time. The dosage itself starts from a low concentration to a high one and then gradually decreases again. The reduction is necessary so that the recovery course after completion of the course is as successful as possible. In general, oxymethalone is not for dummies; it should be used by those who have been on another “pharmacy” for at least 1-1.5 years.
Combining Oxymetholone with Testosterone to Increase Strength and Mass #1
According to this scheme, testosterone needs to be injected once every 7 days, in other words, the entire weekly dose is administered at one time.
Combination of oxymetholone with testosterone to increase strength and mass No. 2
This option is more powerful than the previous one; from the seventh week, oxymethalone is replaced with turinabol with a gradual reduction in doses. This technique will make it possible, at the end of the course, to reduce the concentration of fat and water in the body, as well as reduce the rebound in general.
Scheme for mass and force for MS
The above method of reception is for enhanced strength growth and serious indicators in the mass. The use of Proviron is due to its ability to block fluid accumulation and other side effects that testosterone has.
Reception scheme for prof. fitness and bodybuilding competitions
This scheme is only suitable for professionals and is not even worth it for amateurs. The course includes 2 periods - increasing muscle mass from weeks 1 to 8 and drying the body from weeks 9 to 16, then comes the turn of the competition itself.
Contraindications
According to the instructions for use of Oxymetholone, the contraindications to the drug are as follows:
- excessive sensitivity to the product;
- IHD;
- breast cancer, prostate cancer, breast carcinoma;
- nephrotic syndrome and nephritis;
- severe atherosclerosis;
- kidney and liver failure;
- chronic and acute prostatitis;
- lactation period and pregnancy.
If negative reactions occur, you should stop taking the drug immediately and consult a doctor.
Side effect(s) of oxymetholone
Side effects that deserve special attention are liver toxicity and increased prolactin. In this regard, everyone who uses this steroid is recommended to regularly monitor their hormonal profile, as well as maintain a high-quality diet, take hepatoprotectors and antiprogestogens.
To avoid an excessive increase in progestins, it is strictly not recommended to combine oxymetholone with trenbolone and nandrolone.
Despite the almost complete lack of effect on estrogens, the drug is still capable of causing gynecomastia and swelling. Why? This has already been mentioned above in the article. So, let's take a closer look at the list of side effects:
- Anabolic steroids can reduce blood glucose concentrations. Patients with diabetes should be closely monitored for signs of hypoglycemia and the dose of the hypoglycemic agent adjusted as needed.
- The occurrence of oligospermia and a decrease in fluid volume during ejaculation.
- Older men may experience an enlarged prostate gland, which leads to bladder obstruction.
- Development of priapism.
- Female patients may experience virilization including: deepening of the voice, hirsutism, acne, clitomegaly (not reversible) and menstrual abnormalities. Discontinuation of anabolic steroids when signs of mild virilization occur may prevent irreversible virilization. Changes in libido (increase/decrease) may occur.
- Hepatic tumors associated with anabolic steroid use are more vascular than other liver tumors. Tumors may remain asymptomatic until life-threatening abdominal hemorrhage develops. Peliosis hepatitis can manifest as mild liver dysfunction leading to liver failure. Cholestatic hepatitis, jaundice, and abnormal liver function tests may occur at relatively low doses.
- Oncologic side effects have included hepatic neoplasms and hepatocellular carcinomas following long-term, high-dose anabolic steroid therapy.
- Hematologic side effects include changes in coagulation factors II, V, VII, and X, prolonged prothrombin time (PT), and increased red blood cell production. Leukemia has been reported to be rare during treatment with oxymetholone in patients with aplastic anemia. A causal relationship has not been established, and leukemia has been observed in patients with aplastic anemia who have not received oxymetholone.
- Endocrine side effects include inhibition of endogenous testosterone release through hypotital luteinizing hormone (LH) feedback inhibition. Large doses of exogenous anabolic steroids can suppress spermatogenesis through inhibition of pituitary follicle-stimulating hormone (FSH). The androgenic activity of anabolic steroids may decrease thyroxine-binding globulin levels and result in decreased total serum T4 levels and increased T3 and T4 resin absorption. Free thyroid hormone levels remain unchanged, and there is no clinical evidence of thyroid dysfunction.
- Metabolic side effects include osteolytic hypercalcemia in immobilized patients or patients with metastatic breast disease. Anabolic steroids affect electrolyte balance, nitrogen retention, and urinary calcium excretion. Decreased glucose tolerance, requiring adjustments in hyperglycemic control, has been noted in patients with diabetes. There was a significant increase in low-density lipoprotein (LDL) and a decrease in high-density lipoprotein (HDL), which may contribute to an increased risk of atherosclerosis.
- Psychiatric side effects include addiction, agitation, insomnia, depression, and changes in libido.
Contact your doctor if:
Get emergency medical help if you have any of these signs of an allergic reaction while taking oxymetholone: breakouts, difficulty breathing, swelling of your face, lips, tongue, or throat.
Long-term use of oxymetholone can lead to liver tumors or blood-filled cysts in the liver or spleen. Call your doctor right away if you have: nausea, stomach pain, rapid weight gain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes).
Also call your doctor right away if you have: painful or difficult urination, painful erections, decreased libido, impotence, trouble having an orgasm, decreased sperm count when ejaculating, easy bruising or bleeding (nosebleeds, bleeding gums).
Side effects
Oxymethalon is almost never produced in liquid form, and so far you can only find a remedy from Farmakom Labs; the use of tableted 17-alkylated steroids has a toxic effect on the liver. The advantage of the substance is the absence of estrogenic activity. However, despite this, cases of edema, gynecomastia, and excessive accumulation of fluid in the human body are common. The steroid is structurally a derivative of dihydrotestosterone and does not have a progestogenic effect. Sometimes the following side effects occur: loss of appetite, mild nausea, diarrhea. Oxymethalone, compared to most steroids, reduces the content of endogenous testosterone less.
Reviews
Athletes consider the steroid one of the most dangerous. The remedy is advisable when building a course, starting with the smallest dosages. Divide the daily norm into several equal shares to ensure the same hormonal levels. Athletes note a rapid increase in strength and muscle mass.
The female audience very rarely responds to the drug; girls almost never use the steroid due to the increased likelihood of masculinization and virilization.
We looked at how to take Oxymetalon.
Reception features
For 1 full oxymethalone course, you can increase your weight up to 15 kg, but this does not mean that it will always be pure muscle mass. This steroid directly affects estrogen and progesterone, causing the accumulation of increased concentrations of water in the body, as well as an increase in the proportion of fat mass. In addition, collagen synthesis is enhanced in ligaments and joints, which, with massive accumulation of water, improves the functioning of the musculoskeletal system.
It is difficult to maintain the acquired result; a setback occurs even if you switch to light pharmaceuticals, and even more so if you completely abandon them.
