MSM - methylsulfonylmethane - characteristics, properties, application and dosage

Although you may never have heard of it, the organic sulfur compound known as Methylsulfonylmethane ( MSM ) is found in minute amounts in everyone's blood and in most foods. It is not fully understood what role MSM plays in the complex chemistry of the human body, but some experts believe that, like other sulfur compounds, it is an essential building block for proteins, especially those in hair, muscles and connective tissues of joints and skin. Sulfur is also found in insulin and bile acid.

Methylsulfonylmethane (MSM): properties

Unknown to most of us, sulfur is one of the five essential elements of life. Sulfur is an essential component in human nutrition. It is found in every cell of the body and is structurally and functionally important for 150 compounds, including hormones, enzymes, antibodies and antioxidants. MSM provides an essential portion of the sulfur needed for a number of compounds in the body.

Methylsulfonylmethane is one of the main components of various compounds and processes in the body, and is also necessary for the synthesis of collagen, immunoglobulin and enzymes. In the body of MSM :

1. Maintains flexibility and permeability of cell membranes, promoting efficient metabolism.
2. Ensures connective tissue health and collagen formation.
3. Provides the body with the raw materials it needs to create new cells and to repair and replace damaged tissues and organs.
4. Features in energy production, as a component of insulin and a prerequisite for normal carbohydrate metabolism.
5. It is important in maintaining the acid-base (pH) balance in the body.
6. It is an activator of thiamine, vitamin C, biotin and pantothenic acid.

What is MSM?

In its full name it is called methylsulfonylmethane or methane methyl sulfate or dimethyl sulfone. In the human body, sulfur ranks third in quantity. Most of it is stored in muscles, bones and skin. It is an organic compound found in natural foods such as fruits, vegetables, grains, cow's milk and tea. In its pure form, MSM resembles a white powder, which is characterized by good solubility and odorlessness. Organic sulfur is an extremely fragile compound that is easily destroyed, for example by too low or high temperature, pasteurization or storage. Due to the instability of MSM, it is absent from most grown fruits and vegetables.

Methylsulfonylmethane: health benefits

It is assumed that MSM inhibits pain impulses that travel along nerve fibers, acting as a pain reliever. This property, along with the compound's potential anti-inflammatory effects, is often cited in explaining its use to combat symptoms of arthritis, fibromyalgia, carpal tunnel syndrome, and allergies.

Additionally, MSM may reduce muscle spasms, increase blood flow, and possibly promote cartilage repair and healing. Research in rats suggests that MSM may help delay the growth of certain types of malignant tumors.

Methylsulfonylmethane: allergy

Dietary sulfur plays an important role in relieving allergy symptoms by detoxifying cells and eliminating free radicals. An allergic reaction occurs when the immune system reacts to substances called allergens, which are foreign bodies in the body.

Methylsulfonylmethane helps stabilize cell walls and increase their permeability and elasticity, which allows them to get rid of toxins and foreign bodies, including allergens.

Sulfur compounds and human health

Sulfur-containing amino acids are extremely important for maintaining the integrity of cellular systems. They affect the ability to produce glutathione, which is present in every cell of the body and protects DNA.

Glutathione is a key player in the organs' ability to neutralize free radicals, reactive oxygen species, and detoxify toxic compounds. Low glutathione levels create a strong susceptibility to genetic damage and the development of chronic inflammatory diseases.

Glutathione has two main states within the body: reduced glutathione (GSH) and oxidized glutathione (GSSG). Reduced glutathione is a linear tripeptide of L-glutamine, L-cysteine ​​and sulfhydryl glycine.

The sulfhydryl group has strong electronic character. As the molecule loses electrons during oxidation, the disulfide bridge creates the GSSG form. Oxidized glutathione is converted back to GSH upon repeated electron reduction.

GSH and GSSG coefficients

GSH and GSSG levels are tightly controlled both inside and outside the cell. The ratio of GSH to GSSG in cells is often used by scientists and physicians as a measure of cellular toxicity and oxidative stress. In healthy cells and tissues, more than 90% of glutathione is in the form of GSH and less than 10% in the form of GSSG.

The higher the GSH/GSSG ratio, the healthier the cell and the lower its susceptibility to destruction and genetic mutation. The ratio of extracellular GSH to GSSG indicates the overall oxidative state of blood plasma.

Methylsulfonylmethane is capable of donating electrons to GSSG, but also promotes the formation of GSH. It has a beneficial effect on the body's ability to cope with oxidative stress, protecting intracellular organelles and components of extracellular tissues (blood vessels, intestinal mucosa and lungs), because these areas are most affected by reactive oxygen species. But that's not all the beneficial properties.

Methylsulfonylmethane: bones and joints

Sulfur is critical to connective tissue health, which is why MSM is an important component in treating arthritis and other forms of joint inflammation. In patients with arthritis, the concentration of sulfur in cartilage is only about one-third that of normal tissue.

Methylsulfonylmethane may help treat arthritis due to its anti-inflammatory benefits and maintaining connective tissue elasticity and firmness, along with natural ingredients such as boswellia, vitamin C, glucosamine and chondroitin.

MSM and hyaluronic acid in one capsule For joints, hyaluronic acid is an essential component of synovial fluid, which affects its viscosity. Roughly speaking, it is a lubricant for joints. Moreover, hyaluronic acid has a positive effect on the elasticity of cartilage tissue, preventing it from wearing out.

Research has shown that MSM helps:

1. Improve joint flexibility;
2. Reduces stiffness and swelling;
3. Improves blood circulation;
4. Reduces pain and swelling associated with arthritis;
5. Restores scar tissue and destroys calcium deposits;
6. Improves cell viability;
7. Helps prevent cartilage degeneration when combined with cetyl myristoleate.

Sulfur and its benefits for the body

The main beneficial properties of methylsulfonylmethane:

1. The substance is necessary for the interaction of keratin and collagen, which are responsible for the condition of the skin, nails and hair.
2. It is a strong protector of the body from allergic manifestations, relieving severe symptoms of asthma and allergies.
3. Sulfur is involved in the production of immunoglobulins, which strengthen the body's protective functions.
4. This is one of the components of the hormone insulin, which is responsible for the level of glucose in human blood. Reduces the risk of complications in diabetes mellitus.
5. Participates in the formation of bile.
6. Sulfur helps form cartilage tissue and is part of it. Relieves inflammation in myositis, arthritis and other diseases.
7. All biochemical and metabolic processes cannot do without this substance.
8. Maintains the integrity of connective tissue necessary for mucous membranes, joints, cartilage, ligaments and other organs.
9. Takes part in the synthesis of the amino acids tairine, cysteine, methionine, which are necessary for the formation of the antioxidant glutathione.
10. Methylsulfonylmethane is used to detoxify the body from waste, toxins, and allergens. Allows you to neutralize harmful components.
11. Reduces oxidative processes and fights many diseases.
12. In general, it is necessary to maintain beauty and youth, and is also part of enzymes.

What is sulfur? Recommendations for use

Methylsulfonylmethane: skin and hair care

The sulfur provided by MSM produces generous amounts of collagen and keratin, both of which are vital for healthy hair and nails. In fact, MSM is often referred to as the “beauty mineral” due to its ability to increase the thickness and strength of nails as well as hair in a very short period of time. Moreover, the study also shows MSM is quite beneficial in treating skin conditions such as:

1. Psoriasis,
2. Eczema, in combination with zinc,
3. Rosacea,
4. Dermatitis,
5. Pimples and acne,
6. Dandruff.

Sulfur in cosmetology

In addition to oral use of drugs containing sulfur, there are products for external use, such as lotions, soaps and shampoos. They are most often used by cosmetologists. They help fight dandruff, remove acne and smooth out facial wrinkles. Shampoos containing sulfur prevent hair loss and strengthen hair follicles. The effect of application becomes noticeable after the third application.

Analogues and cost of the product

Analogues and cost of the product

Methylsulfonylmethane has its analogs. The most common are:

1. Honda Drink Evalar.
2. Artron Triactive.

The average cost of such a product in Moscow is approximately 240 to 300 rubles per package.

Consumer comments

Just recently I was faced with the problem of hair loss. I went to a trichologist, after an examination he said that I didn’t have enough sulfur in my body. I assumed that the doctor would prescribe me medications, but he simply recommended shampoo with MSM. I thought that this would not help me, since I used so many different products against hair loss. But after using it for a week, I was pleasantly surprised - my hair stopped falling out and became stronger.

Galina

Every morning I start by jogging, but over time I began to feel crunching in my knees and aching pain. Every day it became more and more difficult to train, my legs began to hurt and get tired quickly. The doctor prescribed this supplement for me. After taking it for two weeks, the pain disappeared and I stopped feeling discomfort when moving.

Tatiana

I spend a lot of time standing on my feet because that's my job.
A year ago I started having pain in my knees. The constant feeling of tiredness in my legs led me to quit my job. After going to the hospital, I was prescribed this remedy. I took it for three weeks and felt a significant improvement. Svetlana

Methylsulfonylmethane: a natural energy carrier

We said above that MSM increases cell permeability. Due to this increased permeability, these cells need less energy to deal with accumulated toxins. Additionally, due to detoxification, it becomes easier for the body to absorb nutrients and in turn reduces the amount of energy spent on digesting food.

Haemorrhoids. Using a gel containing MSM , hyaluronic acid and tea tree oil may improve hemorrhoid symptoms.

Rosacea - rosacea. The use of a cream containing MSM and Vitamin E improves skin color and reduces the symptoms of rosacea.

Stress caused by physical activity. Taking MSM internally before exercise reduces muscle damage and other markers of body stress caused by exercise.

Structure and chemical properties

MSM and the corresponding sulfoxide, dimethyl sulfoxide ((CH3)2TAA, or DMSO), have different physical properties. MSM is a white crystalline solid at room temperature (melting point = 109 °C), whereas DMSO is typically a liquid (melting point = 19 °C). Sulfoxide is a very polar aprotic solvent and miscible with water; it is also an excellent ligand. MSM is less reactive than DMSO because the S-atom of the sulfone is already in the highest oxidation state (VI). Indeed, the oxidation of sulfoxide produces a sulfone both in vitro and metabolically.[5]

Methylsulfonylmethane: additional benefits

1. Helps treat gastrointestinal problems such as diarrhea, nausea, constipation and acidity.
2. Helps in getting rid of snoring when taken diluted with 16 percent water.
3. Helps with painful conditions such as cramps, headaches and muscle pain, especially those caused by hormonal imbalance.
4. Cures carpal tunnel syndrome.
5. Helps balance blood sugar levels.
6. Reduces overall stress levels.

Methylsulfonylmethane is also used to treat ulcers, a bowel disease called diverticulosis, premenstrual syndrome, obesity, in combination with bromelain, poor circulation, high blood pressure and high cholesterol. It is also used to treat liver problems, Alzheimer's disease, lung diseases including emphysema and pneumonia, chronic fatigue syndrome, autoimmune diseases (systemic lupus erythematosus), HIV infections and AIDS, and in combination with quercetin also cancers (breast cancer and colon cancer).

MSM from Coral Club - bioavailable sulfur

METHYLSULFONYLMETHANE PRICE

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One capsule of organic sulfur (msm) from Coral Club contains a complex of methylsulfonylmethane (750 mg), biotin (50 mcg) and vitamin C (50 mg).

This three-component formula enhances each other’s action and has a number of advantages:

• strengthens hair, skin and nails;
• supports the health of cartilage, ligaments and joints;
• has an antioxidant effect;
• affects the synthesis of connective tissue proteins.

These components were added to methylsulfonylmethane because they interact perfectly with it and work in synergy.

Each of the components has beneficial properties:

Biotin or vitamin B7

Normalizes blood sugar levels, activates the growth of beneficial bacteria, restores the functions of mucous membranes and skin, participates in metabolism, and nourishes the brain. Vitamin B7 prevents the appearance of early gray hair, acne and eliminates fine wrinkles, seborrhea, and flaking.

Vitamin C

Plays an important role in the renewal of connective tissue, protects the skin from exposure to ultraviolet radiation, and takes part in the formation of collagen. This is the best antioxidant that supports the health of the entire body at the cellular level and protects it from free radicals.

Methylsulfonylmethane

Accelerates healing, hair and nail growth, reduces pain, neutralizes the effects of toxins on the body, prevents inflammation, is part of enzymes, and participates in the synthesis of hormones and collagen.

All these three components are an active synergistic complex, which, when combined correctly, gives amazing results!

Methylsulfonylmethane reviews

METHYLSULFONYLMETHANE BUY

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Methylsulfonylmethane instructions

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After registering on the Coral Club website

You can also additionally consult with your doctor or a consultant at the company.

In general, the optimal daily dose is 1–2 grams. Therefore, before choosing a supplement, be sure to look at the amount of the active substance, because... There are 100-300 mg of it in a capsule, and the price is very high.

It also happens, on the contrary, a high price may indicate that the product contains not only sulfur, but also other components that work well together and help to recover faster (chondroitin and glucosamine sulfates, fatty acids, manganese, vitamin C).

Read more “FlexiCor is a complex that prevents the destruction of osteochondral tissue and improves the functioning of the musculoskeletal system.”

Contraindications

The product should not be taken during pregnancy or lactation. Due to contraindications, it is forbidden to drink methylsulfonylmethane if you are hypersensitive to its components.

Side effects

There is no information about overdose and negative effects. Harm from methylsulfonylmethane is observed only in case of individual intolerance, stool upset, nausea, and vomiting are noted.

A clinical study was also conducted to confirm this fact. The longest study on MSM use to date is 26 weeks. However, no negative effects were detected even when using 6 grams per day.

Methylsulfonylmethane: content in products

Ideally, it's best to get your sulfur from the foods you eat. However, this can be a bit of a challenge these days.

You can probably get enough MSM by making bone broth and using the infusion regularly (or using it to make soups and stews). Connective tissue is rich in sulfur , and when you slow cook bone broth, you dissolve these nutrients from the bones into the water.

Methylsulfonylmethane is found in almost all raw foods. Especially in green leafy vegetables. Interestingly, MSM is found in beer and coffee. Raw milk has the highest natural MSM .

There is one caution when cooking and pasteurizing. While MSM is resistant to changes in pH and temperature, it also evaporates and turns into gas very easily. And also easily soluble in water. Therefore, when cooked at high temperatures, it simply turns into steam. This is why it is easily removed during cooking and cooking. Pasteurization reduces the MSM by about 50 percent. So, in order to ensure that you are getting MSM from any food, it should be raw or as minimally processed as possible.

What foods contain MSM?

Each product contains sulfur, the only difference is its concentration. Most sulfur is found in:

• legumes;
• any type of cabbage;
• vegetables of the red family;
• cereals;
• horseradish;
• all greens, including dandelion;
• avocado;
• green vegetables;
• eggs;
• bakery products;
• meat;
• mustard;
• soy;
• fish;
• bananas.

Important! Sulfur is quickly destroyed in products during heat treatment, when treated with pesticides and long-term storage, so modern people have a deficiency of this substance.

Methylsulfonylmethane: dosage

1. For arthritis: Take 500 mg two or three times daily. Using MSM in addition to supplements may provide additional benefits. Rub the cream onto the painful area 4-5 times daily for best results.
2. For back pain: Take 500 mg three times daily. Using MSM in addition to supplements may provide additional benefits. Rub the cream onto the painful area 4-5 times daily for best results.
3. For allergy symptoms: Take 500 mg twice daily.

Based on research, the suggested therapeutic dose of methylsulfonylmethane is two to 10 grams per day, based on one gram of MSM per kilogram of body weight.

In what cases can MSM help?

At the first signs of inflammation in the joints, regardless of a person’s lifestyle, a methylsulfonylmethane supplement should be taken in the recommended dose and method of administration. Sulfur is naturally lost with age, and its supply is insufficient from food, so dietary supplements can be used by those people who have felt pain, grinding, and inflammation in the joints.

Pain in the ligaments and joints caused by constant and intense physical activity can also be removed with the help of methylsulfonylmethane. The compression load of power sports, as well as loads associated with running, jumping movements, where deformation of cartilage tissue occurs, over time leads to pain, more often in the knee joints, wrists, elbows and hips. In this case, you also cannot avoid taking a supplement, preferably in addition to chondroprotectors. Since the substance can not only relieve inflammation, but also regenerate cartilage and ligaments, you can take the supplement without giving up your usual exercise.

Important ! During the period of the inflammatory process, it is worth either stopping training (in case of acute pain), or significantly reducing the weight of the load, training more in endurance mode; exercises should be aimed at strengthening the ligamentous apparatus, and not re-injuring it.

Methylsulfonylmethane: recommendations for use

1. Take MSM with or immediately after meals to reduce the possibility of gastrointestinal upset.
2. If you find that MSM increases your energy levels, avoid taking it too close to bedtime.
3. For most conditions, you need to take it for at least a month to see results.

Possible side effects of methylsulfonylmethane:

All medicines can cause side effects, and many people experience few or no side effects. Check with your doctor if any of these most common side effects appear and become bothersome:

• Diarrhea,
• Headache,
• Nausea.

Get medical help right away if any of these serious side effects occur:

• Severe allergic reactions - rash;
• Itching;
• difficulty breathing or swallowing;
• Heaviness in the chest;
• Swelling of the mouth, face, lips, or tongue.

How to dose MSM supplements?

The level of sulfur in the human body is approximately 0.2 mg/kg. The amount excreted by the adult human body ranges from 4-11 mg/day. The general starting dose is 1 g/day. If there are no side effects, the dose should be gradually increased. The maximum recommended dose is 5 g of methylsulfonylmethane per day. In addition to gradually increasing the amount of MSM, there is also a method of saturating the body with sulfur. This method involves the use of methane methyl sulfate in an amount of 15 g per day, preferably in three smaller doses. Such treatment should not last longer than a month, and after its completion it is recommended to return to standard doses - 3-5 g per day. Due to its blood-thinning properties, it is not recommended for people taking drugs with similar effects, such as aspirin.

To adjust the starting dose in direct proportion to the individual, it is worth consulting with a doctor or nutritionist.

Methylsulfonylmethane: buy, price

Here is such a large assortment of forms, dosages and manufacturers of methylsulfonylmethane :

Buy capsules, tablets and powder of Methylsulfonylmethane!

1. You can buy methylsulfonylmethane at a low price and with guaranteed high quality in the famous American online organic store iHerb, so beloved by residents of Russia and the CIS (purchase in rubles, hryvnia, etc., reviews in Russian for each supplement). 2. Detailed step-by-step instructions for placing an order (very simple): How to place an order on iHerb! 3. When ordering, you can use the iHerb promotional code and get real benefits - $5 discount for new customers and 5% for “old” customers (without ADDITIONAL DISCOUNTS), as well as profitable Promotions up to 60%! We recommend that you use the M.Video promo code and get additional discounts on equipment and electronics! Look and use profitable promotions using the Yandex Market promo code for your first order to receive discounts and participate in sales. Use the Ozone promo code for dozens of promotions. Apply the popular Sbermarket promotional code for your first delivery order, as well as the Adidas promotional code for savings of up to 70% in the official online store! 4. Detailed articles about the intricacies of delivery and payment: iHerb payment and iHerb delivery!

Photo source: iHerb.com

What should you pay attention to when choosing a dietary supplement with MSM?

There are now many companies on the market offering various MSM supplements. Therefore, everyone asks the question: “How to choose a quality one?”

1. First of all, it is important that the product is of organic origin!
2. Secondly, read reviews about the company that sells this product and who the manufacturer is.
3. It is also important whether the company has all the necessary quality certificates and what else is included in the dietary supplement, and how many mg of the active ingredient.

This is very important because... This will determine how quickly you feel the results from using methylsulfonylmethane.

If all of the above criteria are important to you, you can replace trips to regular pharmacies and stores with the Coral Club eco-market.

I and my whole family have been using the products of this company for more than 5 years. I often use this company's MSM product in various complex programs. The last of the results on osteochondrosis.

There was severe inflammation of cervicobrachial osteochondrosis. We used MSM + Bi Luron + Boswellia + special gymnastics. Within a month the pain was gone.