Peptide TB 500: how to take, side effects and reviews

The peptide, marketed under the trade name “TB 500,” is an analogue of the anthropogenic one, which is obtained as a result of the synthesis of forty-four amino acids. The drug promotes healing and restoration of wounds. For medical purposes, it is taken after a heart attack, injury or surgery. For horses, this drug is a doping agent. In bodybuilding, bodybuilders take this peptide in order to achieve an anabolic effect.

TB-500 (Thymosin Beta 4, Thymosin Beta 4)[edit | edit code]

Structure of TB-500
TB-500

(lab code RGN-352) is a synthetic version of a naturally occurring 44 amino acid peptide found in all human and animal cells, thymosin beta 4 (TB4). The use of TB-500 accelerates the healing of wounds and injuries and exhibits a multidirectional protective effect. Recent testing has shown that TB-500 has some effect on athletic performance. For the first time, Thymosin Beta 4 was isolated from thymus extract.

In medicine, it is used to accelerate the healing of wounds associated with various diseases[1], as well as to restore the myocardium after a heart attack, and treat ischemic conditions.[2]

Contrary to popular belief, it is determined by liquid chromatography.[3] Began to be used as a doping for horses participating in racing.

Information

• Manufacturer
  : bluepeptides.com;
• Bottle size
  : 2 mg;
• Purity
  : >98%;
• Amino acid sequence
  : Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln -Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH;
• Molecular formula
  : C212H350N56O78S;
• Molecular weight
  : 4963.55 grams/mol;
• Approximate half-life
  : unknown;
• Warning
  : Not a drug or pharmaceutical substance. For research purposes only;
• Shelf life
  : 5 years;
• Storage conditions
  : the drug should be stored in refrigerators at temperatures from 2 to 8°.
• Peptide analysis
  : this peptide is tested by high performance liquid chromatography (HPLC) in the silverpharm laboratory
• Checking the unique analysis code
  : you can view the analysis results on the official website of the company silverpharm.ru - by entering the research code 7BF5FD2E (eng), the results are also posted at the end of this article;
• Wholesale

Effects[edit | edit code]

• Accelerates the recovery of muscles (including heart muscle), ligaments, joints[4] and skin. It has a pronounced reparative potential for many tissues.[5]
• Anti-inflammatory effect[6]
• Angiogenesis is the growth of new blood vessels in the muscles, which improves their nutrition.[7]
• Protects and restores the nervous system.[8]
• Stimulates the secretion of luteinizing hormone, and as a consequence testosterone.[9]
• Increases tissue sensitivity to the anabolic hormone insulin.[10]
• Increases joint mobility and ligament stretchability.
• It is a cardioprotector and reduces the risk of myocardial infarction [11], restores the myocardium [12]. It has regenerative properties even during myocardial ischemia. [13]

TV-500 does not have a significant effect on muscle growth and strength indicators.

Side effects of TB 500

Even with multiple increases in the maximum dosage, not a single side effect was identified during the tests.

The absence of side effects, medicinal substances and effectiveness make this peptide a fairly high-quality product. The regenerative abilities far exceed any other sports supplement, however, the anabolic functions of TB 500 are not as pronounced.

If you want to use this peptide most effectively, it is recommended to combine it with sports nutrition or other peptides.

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Course[edit | edit code]

Thymosin Beta 4 is administered subcutaneously or intramuscularly. It is recommended to use only for treating injuries and strengthening the heart.

• Loading phase
  : dose of 2-6 mg per week[14][15], divided into two injections (for example, 2 mg: Monday, Wednesday). Duration 1 month.
• Maintenance phase
  : 2-4 mg per
  WEEK
  , divided into 2 injections. Duration 1-2 months.

Alternative scheme:

a loading dose of 10 mg in the first week (1-2 mg per day), then 5 mg per week (optimally divided into 2 injections) for 5 weeks and a maintenance dose of 10 mg per month (2 mg every 6 days) is optimal and effective according to many US athletes using TV500. In total, we get 18 bottles of 2 mg for the first 6 weeks + 5 bottles of 2 mg per month to maintain results.

Preparation and storage of the solution

You should cool the bottle to room temperature and introduce the required volume of water for injection (which should flow down the wall of the bottle), then stir with a rotating motion (do not shake), or put it in the refrigerator for a while. Also, Y. Bombela writes that it is better to use saline solution, which allows it to be frozen.

In the refrigerator, the solution remains stable for about 8 days, in a frozen state - up to a month.

How to take TB 500 – course

Courses on how to take TB 500 vary greatly from person to person. Some take it on an ongoing basis, others for 2-3 weeks. Research has found that the optimal course duration is about two months. After this, the effectiveness of the drug declines and it has a less pronounced effect.

It can be used with or without a loading phase.

And now about how to inject TB500...

Injections – subcutaneously or intravenously.

With loading:

• The first week – 20 mcg per 1 kg of weight per day. That is, if you weigh 100 kg, you should consume 2000 mcg of this peptide;
• Second week – we reduce the dosage to 15 mcg per 1 kg of weight. After this, the loading phase is completed;
• Starting from the third week - 10 micrograms per 1 kg of weight.

Without download:

This regimen of use is more suitable for those who use this peptide precisely because of its regenerative abilities. Daily dosage – 10 mcg per 1 kg of body weight.

Sources[edit | edit code]

1. Trials sponsored jointly by RegeneRx Biopharmaceuticals Inc (Rockville, MD, USA) and Sigma Tau (Pomezia, Italy) in the United States and Europe
2. Smart N, Bollini D, Dubé KN, Vieira JM, Zhou B, Davidson S, Yellon D, Riegler J, Price AN, Lythgoe MF, Pu WT, Riley PR (June 2011). "De novo cardiomyocytes from within the activated adult heart after injury." Nature 474 (7353). doi:10.1038/nature10188. PMID 21654746. Lay summary - BBC News.
3. Esposito S, Deventer K. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012 Sep;4(9):733-8. doi: 10.1002/dta.1402. Epub 2012 Sep 7.
4. Michael R. Bubb, MD, Use of thymosin beta4 to treat osteoarthritis.
5. Crockford D, Turjman N. Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications. Ann NY Acad Sci. 2010 Apr;1194:179-89.
6. Young JD, Lawrence AJ, MacLean AG, et al. (December 1999). "Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids." Nat. Med. 5 (12): 1424–7.
7. Riley PR, Smart N (December 2009). "Thymosin beta4 induces epicardium-derived neovascularization in the adult heart." Biochem. Soc. Trans. 37 (Pt 6): 1218–20
8. Xiong Y, Mahmood A, Neuroprotective and neurorestorative effects of thymosin β4 treatment following experimental traumatic brain injury. Ann NY Acad Sci. 2012 Oct;1270:51-8
9. Rebar RW, Miyake A, Thymosin stimulates secretion of luteinizing hormone-releasing factor. Science. 1981 Nov 6;214(4521):669-71.
10. Zhu J, Su LP, Ye L, Lee KO, Ma JH. Thymosin beta 4 ameliorates hyperglycemia and improves insulin resistance of KK Cg-Ay/J mouse. Diabetes Res Clin Pract. 2012 Apr;96(1):53-9. Epub 2012 Jan 3.
11. Bao W, Ballard VL, Needle S, Hoang B, Lenhard SC, Tunstead JR, Jucker BM, Willette RN, Pipes GT. Front Pharmacol. 2013 Nov 29;4:149. doi: 10.3389/fphar.2013.00149. eCollection 2013.
12. Ye L, Zhang P, Duval S, Su L, Xiong Q, Zhang J. Circulation. 2013 Sep 10;128(11 Suppl 1):S32-41. doi:10.1161/CIRCULATIONAHA.112.000025.
13. Smart N, Bollini S, Dubé KN, Vieira JM, Zhou B, Riegler J, Price AN, Lythgoe MF, Davidson S, Yellon D, Pu WT, Riley PR. Ann NY Acad Sci. 2012 Oct;1269:92-101. doi: 10.1111/j.1749-6632.2012.06708.x.
14. https://www.fasebj.org/content/22/3/659.full.pdf
15. https://tnation.t-nation.com/free_online_forum/sports_training_performance_bodybuilding_gear/thymosin_beta_4
16. Ruff D, Crockford D, Girardi G, Zhang Y. A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. Ann NY Acad Sci. 2010 Apr;1194:223-9.
17. Tang MC, Chan LC. Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway. Cancer Lett. 2011 Sep 28;308(2):162-71. Epub 2011 May 28.

How are peptides superior to growth hormones?

Most of the peptides synthesized by scientists are almost completely free of contraindications and side effects from overdose.

Peptides have a number of advantages in relation to growth hormones:

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• taking peptides does not create a risk of atrophy of the glands that synthesize hormones;
• the cost of a course of taking peptides is much lower than a course of taking growth hormones;
• sale and purchase of peptides is legal;
• it is possible to control the level of growth hormone when taking peptides;
• peptides have a short decay period, their stay in the body is minimal.

At the same time, peptides help bodybuilders:

• speed up metabolic processes;
• increase the rate of muscle mass growth;
• accelerate the rate of fat burning;
• increase immunity;
• strengthen cartilage and bones;
• reduce the recovery period after training;
• stimulate the functions of growth hormone.

Peptides also help maintain muscle and skin tone, normalize sleep and overall rejuvenation of the body.

Peptide supplementation programs

By properly combining high-intensity training, a healthy diet and courses of taking peptides, you can achieve very outstanding results in bodybuilding.

You can use both mixed type peptides - structural and functional, or form a course of parallel administration of several drugs with a unidirectional effect. In the second case, the effectiveness will increase due to the achievement of a synergistic effect - the mutually reinforcing effect of the peptides on each other. This could be one of the courses:

1. GHRP-2

The goal of the peptide course is to build muscle mass and increase strength.

To do this, you need to inject GHRP-2 peptide four times a day, 200-250 mcg, for 2 months. In total you will need 10-12 bottles of the drug.

The advantages of this course are its low cost and high degree of effectiveness.

Side effects. Possible reduction in sugar levels. To avoid this, you need to provide the body with a carbohydrate boost before injection.

1. GHRP-2+ GHRP-6

Goal of the course: gain weight and increase strength.

The course lasts 2 months. Administer 150-200 mcg of drugs three times a day an hour before meals or an hour after meals. For a full course you will need 8-10 bottles of each type of peptide.

The advantage of the course is its relative cheapness and rapid onset of effectiveness - after the introduction of peptides, appetite begins to increase, which leads to weight gain.

1. Hexarelin+CJC-1295

Goal: increase muscle size and mass.

This is one of the most potent combinations.

The course will look like this:

The first 2 weeks - 3 injections of Hexarelin per day (50 mcg at a time).

Next 2 weeks: Hexarelin+CJC-1295 – 100 mcg three times a day.

Finally, for a month, 3 injections of CJC-1295 peptide per day (100 mcg per injection).

It will take 4 bottles of CJC-1295 and 3 bottles of Hexarelin.

The advantage of the course, in addition to muscle growth in volume and mass, is the absence of a stimulating effect on appetite, promoting the processes of wound healing, recovery from injuries and fat breakdown, strengthening the condition of the joints.

A side effect in some cases is short-term desensitization (lasts no more than 2 weeks).

1. TB-500

The goal of the peptide course: gain weight and improve endurance.

The course of TB-500 will last for 3 months (23 bottles of the drug), while:

• in the first week, 10 mcg of the drug is administered;
• in the second week you need to give two injections of 2.5 mcg;
• in the next 5 weeks, 1 bottle of 2 mcg will be taken for 6 days.

The advantage of the TB-500 peptide is the improvement of athletes’ performance before competitions, the inability to determine its presence in the body through doping tests.

1. GHRP-2+ GHRP-6+MGF peg.

The goal is to build muscle and gain weight at the maximum permissible rate.

It will take 2 months. Dosages and frequency of injections:

• peptides GHRP-2 and GHRP-6 - administered 3 times a day, 150-200 mcg, an hour after meals or an hour before meals;
• MGF peg peptide. administer subcutaneously (400 mcg of the substance) before training (1-2 hours before it starts).

Over 2 months, 10 vials of GHRP-2 and GHRP-6 and 6 vials of MGF peg will be used.

The injectable form of peptides is the most common. Injections should be given intramuscularly with a regular syringe or the drugs should be injected into adipose tissue with an insulin syringe (in the abdominal area).

Characteristics and purpose

Small chains of amino acids up to 50 units long are peptides. In the human body they are synthesized from proteins and regulate many processes:

• increase and decrease blood pressure;
• trigger the production of gastric juice;
• stimulate the digestion process;
• dull the feeling of pain;
• coordinate sleep, learning, memory and much more.

The functions of peptides are very extensive. Scientists are still discovering the beneficial effects of these substances on the processes occurring in the human body. Among other things, experts have found that peptide chains regulate cell division, so they have a positive effect on the skin, activating collagen production, increasing skin regeneration, and stimulating blood circulation.

Peptides penetrate deeply into the epidermis, and this property also did not go unnoticed by scientists. Research laboratories have learned to artificially synthesize these substances. There are now 7 groups of peptides known that have a beneficial effect on the skin, and therefore are actively used in anti-aging preparations - creams, injections, serums:

• stimulants - promote skin regeneration, actively heal wounds;
• stabilizers - responsible for the protective and antioxidant functions of the dermis;
• blockers - relax facial muscles;
• regulators of melanogenesis - normalize skin color;
• immunomodulators - increase the immune defense of the dermis;
• neurotransmitters - increase the threshold of sensitivity (usually included in cosmetics for sensitive skin);
• substances that affect blood circulation and lymph flow - have a positive effect on the elasticity of blood vessels and have an anti-edematous effect.

Injectable preparations may contain the following peptides (the list is not exhaustive):

• oligopeptide-23 - regulates metabolic processes, participates in the formation of new cells;
• oligopeptide-24 - reduces wrinkles and scars;
• oligopeptide-34 - evens out skin color and brightens it, reduces the number of age spots;
• oligopeptide-72 - prevents the occurrence of wrinkles, smoothes and reduces existing folds;
• oligopeptide-51 - responsible for reducing skin pigmentation;
• decapeptide-29 - reduces the depth of folds and wrinkles, evens out the relief of the skin;
• acetyl decapeptide-3 - has an anti-aging effect;
• copper tripeptide-1 - accelerates skin regeneration and increases its elasticity.

Platinum peptides 70, 81 and 96 are also becoming popular in cosmetology, which improve the color and texture of the dermis.

Indications for use

In the human body, peptides are formed in a few minutes, but in laboratory conditions this requires at least several days. However, with age, the natural processes of substance synthesis slow down. This is reflected in appearance. Injections will help fill the deficiency of peptide compounds in the facial skin. They are relevant in the following cases:

• pale skin, dull color;
• bruises, bags under the eyes;
• pigmentation of the dermis;
• dryness, appearance of wrinkles;
• increased swelling of the face;
• scars, acne scars, etc.

Injectable preparations with peptides are usually used for mesotherapy or biorevitalization. The first can be performed from the age of 18–20, but only if there are medical prescriptions for this. Peptide biorevitalization is a more “age-related” procedure. It is more often recommended to women who have crossed the 30-year mark and want to rejuvenate, moisturize and refresh their skin.

Peptides are also used in laser facial resurfacing and ultraphonophoresis (exposure to the dermis with ultrasound).

Efficiency of use

Peptide injections help solve several skin problems at once in a relatively short time:

• moisturize it and maintain the natural water balance at the proper level;
• smooth out wrinkles;
• evens out the complexion and gives the skin a glow;
• remove age spots;
• rejuvenate the area around the eyes, eliminate swelling, dark circles;
• make the skin more toned and elastic;
• increase the protective functions of the dermis, improve metabolism;
• fight post-acne symptoms.

What danger do peptides hide?

Harm from the use of peptides occurs most often in cases of their incorrect or excessive use. In this case, be prepared for the following side effects:

• The previously mentioned protein poisoning is what most often affects those new to the world of sports supplements who dream of instant muscle growth. Excess peptides lead to excess protein and amino acids, resulting in increased load on the liver, which it cannot always cope with.
• Rash, irritation. They are observed frequently and disappear a short time after the injection.
• Individual reactions of the body to the rapid growth of hormones.
• Deterioration of appetite and subsequent loss of strength.
• Delay in ligament development compared to muscle growth.
• Low-quality or counterfeit peptides, attractive due to their low cost, can lead to poisoning of the body. Therefore, it is better to study reviews and trust only specialized sports nutrition stores.

Bodybuilders are not always unanimous in their opinion that peptides are beneficial and provide tangible results.

Anatoly, 34 years old

I personally did not feel any particular effect from the peptides. The only thing I would like to note is that the recovery period after training has been reduced. As for the rest, there were no global changes - during the two-month course there was no significant increase in muscle mass. So I think that you won’t get far with peptides alone. I have determined the optimal ratio for myself - MGF peg. + AC peptides.

However, the majority is still on the side of peptides.

Dmitry, 29 years old

I took a course of peptides, including melanotan + GHRP-2 + GHRP-6. I am completely satisfied with the results - the weight came off quickly, and muscle mass grew just as quickly. The only side effects were short-term diarrhea and increased appetite in the first week of the course. But in the second week, the condition stabilized, and the appetite decreased significantly. So, compared to the effect obtained, these were very small sacrifices.

Roman, 31 years old

Peptides pleasantly surprised me, so to speak. I especially noticed the increase in the speed of recovery after exercise. And the injuries began to heal faster. After 2.5 months on peptides, my health improved and I began to get sick less. The only thing that caused discomfort was irritation after the injection. However, by the time of the next injection everything went away. But these are very small sacrifices that are worth making for the sake of sculpted muscles.

What effects does taking GHRP-2 peptide cause?

Taking this substance in bodybuilding promotes:

• Increased growth hormone (GH). It is synthesized under conditions that are identical to natural ones, eliminating the need for both T3 and T. This helps maintain the natural metabolic rate. There is also no effect on the functioning of the thyroid gland.
• Rejuvenation of the body. It has been scientifically substantiated and proven that with an increase in the level of androgenic (own) GH, the condition of the nail plate improves, the hair becomes healthier, the skin tone increases, and there are no wrinkles. Hormone maintenance therapy is normal practice in the United States and is prescribed by a regular physician.
• Improved sleep. This property is manifested by the fact that a person spends less time in sleep, but at the same time recovers one hundred percent.
• Getting rid of fat deposits. High levels of GH have been shown to have direct and indirect effects on metabolic rate. The direct effect implies an improvement in metabolism against the background of an increase in muscle mass, and the indirect effect implies an acceleration of fat burning as a result of the body’s increasing need for energy, which arises due to the fact that the active phase of the day increases.
• Increased appetite. This effect occurs temporarily. If the diet is properly balanced, then within two weeks after the start of the course, the appetite returns to normal.
• Improving bone condition. There is an increase in their density, which becomes an excellent prevention against osteoporosis.

An equally important effect of the drug is that it helps reduce “bad” cholesterol in the blood. Among its effects, hepatoprotective and anti-inflammatory are noted.

Action of the peptide

GHRP-6 injections have a wide range of actions that are still being researched. Taking the peptide is generally believed to lead to the following changes:

• Increases the concentration of androgenic growth hormone in the body with all its inherent consequences. The use of the product, as users note, normalizes sleep, helps to recover faster after training, and also reduces body fat without a strict diet and does not feel overtrained.
• Speeds up metabolism and increases appetite. There is no effect of suppressing hunger, but, on the contrary, an incentive to consume more food in relation to growth hormone allows you to gain lean muscle mass.
• Rejuvenates the body. The effect is manifested not only in internal changes, but also in external ones, when the skin is tightened and smoothed.
• Has a beneficial effect on the circulatory system. Blood sugar levels also decrease, and the concentration of bad cholesterol decreases significantly.
• Increases resistance to infections. The body's protective and anti-inflammatory response is enhanced.
• Indicators of muscle endurance increase. This has a positive effect on the training process.

The peptide has effects that allow the drug to be used by those involved in bodybuilding, but it is of little use for weightlifters and powerlifters, since it has practically no effect on strength indicators.

And if most peptides are used for weight loss, then GHRP-6 is not suitable for these purposes without taking other drugs, as it helps increase appetite. The product should be taken by those who not only want to lose weight, but also gain lean muscle mass.

The peptide is recommended for use together with amino acids BCAA, ZMA, GABA and other sports nutrition.

How it was. Peptides. Off-course therapy. Current form

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The effect of the peptide for weight loss

The chemical structure of the drug resembles part of the molecule of human somatotronic hormone (GH). If you use the peptide you can expect:

• Active fat burning. The drug acts on the adrenergic receptors of fat cells and, in case of a lack of calories, can give a certain effect. For those people who use the peptide, it is advisable to follow a diet and exercise.
• Acceleration of recovery processes upon completion of training.
• Strengthens bone tissue, which reduces the likelihood of osteoporosis.
• Rejuvenation of the body.
• Increases performance regardless of diet, helping the body maintain activity with limited nutrition.
• Reduces the effect on insulin levels, which optimizes blood sugar levels.

The only thing that is still unknown is how much the somatotronic hormone increases. The practical use of the HGH Frag peptide (176-191) comes down to its use by those athletes who need muscle relief when the muscle mass has acquired the necessary volumes. The drug is not an anabolic steroid, therefore it is not used in the process of muscle gain. This indicates that it will not be possible to gain impressive amounts of muscle while using it. At the same time, there are rumors that it is actively used in preparation for fitness bikini competitions.